POSITION SUMMARY

The ADC (Antibody Drug Conjugate) Chemistry team discovers and advances novel ADC linker and payload technologies for targeted cancer therapies.  This is a lab-based role that will support novel ADC technology development.  You will participate in research projects involving the design and synthesis of novel ADC payloads and linkers. Your role may also include coordinating or performing biological assays to understand linker, payload and ADC properties. 

KEY RESPONSIBILITIES

• Design and perform multi-step syntheses of novel ADC payloads, linkers, and key intermediates.
• Work independently to develop, troubleshoot and optimize synthetic routes, including modular routes for rapid analog generation and efficient scalable routes for early-stage drug candidates.
• Operate a variety of analytical instruments and technologies including HPLC, LC/MS, NMR to enable structural determination and purity assessment.
• Work effectively in both independent and highly collaborative settings.
• Analyze and accurately record data using Electronic Laboratory Notebooks.
• Actively participate in discussions and present results in the form of written reports and oral presentations.
• Adhere to all company safety, scientific record keeping, and compliance requirements.

MINIMUM QUALIFICATIONS

• Master’s degree with 4+ years industry synthetic organic chemistry experience OR
• Bachelor’s degree with 6+ years industry synthetic organic chemistry experience
• Deep understanding of organic functional groups, reaction mechanisms and reactivity.
• Experience using chemistry and literature/patent searching software to plan and execute synthetic strategies.
• Experience as a synthetic organic chemist familiar with a wide range of reaction types and having demonstrated multi-step synthesis, purification, and characterization of organic compounds, especially using NMR and mass spectroscopy.
• Strong interpersonal skills and effective written/verbal communication.
• Experience working effectively in multi-disciplinary teams, learning new skills and proactively solving problems

  

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

Relocation support available
Work Location Assignment: On Premise

The annual base salary for this position ranges from $77,100.00 to $128,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Research and Development