Scheduled Hours

40

Position Summary

The Perlmutter lab is seeking a talented, highly motivated individual to join our team in the Division of Gastroenterology, Hepatology, & Nutrition of the Department of Pediatrics at WashU Medicine. The lab’s focus is research on the pathobiology of, and treatments for, α1antitrypsin deficiency (ATD), a rare disease in which the misfolded α1antitrypsin protein causes liver fibrosis/cancer by gain-of-toxic function and chronic obstructive lung disease by loss-of-function. One of our major areas of focus is discovery and testing of autophagy enhancer drugs to clear the toxic misfolded protein from the diseased liver.

Over the last 10 years the lab has refined the use of cell line and mouse models for testing of new drug strategies, now focusing mainly on autophagy enhancer drugs. This work has been informed by a novel C. elegans model of antitrypsin deficiency that has been adapted to high-content screening of drug and RNAi libraries for new therapies for other protein aggregation disorders. The lab has now identified a lead candidate autophagy enhancer drug with in vivo efficacy for ATD and also efficacy in cellular models of Huntington’s disease and frontotemporal dementia (tauopathy), therein leading us to also believe this drug series will be ideal for the tauopathy of chronic traumatic encephalopathy.

Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.

Job Description

More information about the Perlmutter Lab (1) and recent publications (2) is available here:

(1) https://pediatricgi.wustl.edu/items/perlmutter-lab/.

(2) PMID: 38557779, 38336172, 38066314, 37214956, 36848094, 36303071, 35301011.

• Following instructions and discussions with the principal investigator, designs research protocols, including developing procedures for the collection, verification and management of data.
• Assists with grant preparation and reporting.
• Performs complex statistical analysis of data collected and writes interpretative reports. Verifies the correctness of the data submitted and makes recommendations based on these analyses.
• Documents research topics and prepares and submits papers based on research work to publications and committees for publication or presentation to peers.
• Solves practical problems relating to difficulties with equipment or test subjects. Suggests technical or procedural improvements in testing methods.
• Conducts literature searches related to research project.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological and chemical hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Master’s degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

Laboratory Operations (3 Years)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.

Preferred Qualifications

Education:

Ph.D. - Doctor of Philosophy

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Analytical Problem Solving, Communication, Computer Literacy, Data Analysis, Data Interpretations, Protein Expression and Purification, RNA Analysis, RNA Purification

Grade

R10

Salary Range

$48,000.00 - $86,900.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.

• Competitive health insurance packages with priority appointments and lower copays/coinsurance.

• Take advantage of our free Metro transit U-Pass for eligible employees.

• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered.

• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.