The Lee Lab research program focuses on advancing translational NK cell therapies for pediatric cancers. Our work spans in vitro function (cytotoxicity, cytokines, avidity), immunophenotyping (mass cytometry), genomics/epigenomics (RNAseq, ATACseq, ChIPseq, methylation), and in vivo xenograft, PDX, and canine models. Current focuses: inhibitory TME (hypoxia, TGFβ, kynurenine), NK checkpoints (TIGIT, TIM3, VISTA), activation (ITAM/ITIM, CAR design, cytokines), and Cas9/AAV engineering. We also perform correlative studies of early-phase NK therapy trials. Disease targets include AML/MDS, brain tumors, pediatric sarcomas, and select adult malignancies. The lab has broad federal, foundation, industry, and institutional sources of support.

 

 

Conducts independent research, designs experiments, analyzes data, and presents findings under the mentorship of a principal investigator. Assists with training and mentorship.

 

 

Essential Functions:

• Designs experiments, develops protocols, and conducts research with faculty PI under minimal guidance.
• Serves as a mentor and training aide to new or junior staff. Trains and supervises technical support staff in performing specific techniques essential to carrying out the research program.
• Records and analyzes data generated by the research study. Assists in the development of hypotheses for further investigation from the results of the studies performed.
• Prepares scientific and technical papers for publication in peer-reviewed journals. Presents findings at local and national research forums.
• Collaborates with other ongoing research efforts either at NCH or at The Ohio State University.
• Works toward research independence, preparing to submit proposals to and obtain funding from external granting agencies.

Education Requirement:

PhD or equivalent degree in relevant field of science, required.

Licensure Requirement:

(not specified)

Certifications:

(not specified)

Skills:

• Effective interpersonal skills required in interactions with scientists, physicians, and laboratory colleagues.
• Excellent laboratory technical skills.
• Excellent computer skills.
• Skills in qualitative and quantitative research methods.
• Ability to proactively manage and drive projects.

Experience:

Research experience from PhD program, required.

Physical Requirements:

OCCASIONALLY: Bend/twist, Climb stairs/ladder, Lifting / Carrying: 11-20 lbs, Pushing / Pulling: 0-25 lbs, Pushing / Pulling: 26-40 lbs

FREQUENTLY: Lifting / Carrying: 0-10 lbs, Standing, Walking

CONTINUOUSLY: Audible speech, Color vision, Computer skills, Decision Making, Depth perception, Flexing/extending of neck, Hand use: grasping, gripping, turning, Hearing acuity, Interpreting Data, Peripheral vision, Problem solving, Reaching above shoulder, Repetitive hand/arm use, Seeing – Far/near, Sitting, Squat/kneel

Additional Physical Requirements performed but not listed above:

Pressure in this position will vary depending on the workload. The workload will be heavy but manageable most of the time. Pressure may arise in the face of deadlines associated research and manuscript writing.

 

 

"The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individuals so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under their supervision. EOE M/F/Disability/Vet"