Research Fellow, PGY1 - Inner Ear Regeneration
- 2410 Brigham and Women's Physicians Organization, Inc.
- Boston-MA
- 7mo ago
- Full-Time
- On-site
...
Site: Massachusetts Eye and Ear InfirmaryOnsite243-245 Charles Street40RegularDay (United States of America)Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.
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Job Summary
Gene therapy and hair cell regeneration have shown great promise as new treatments for hearing loss that does not have any FDA approved drugs. One major obstacle to achieving treatment efficacy is our inability to deliver genes, mRNA, proteins and other molecules into the inner ear cell types efficiently. Dr. Wang’s project is to test new delivery vehicles including viral and non-viral, which can efficiently target diverse inner ear cell types with minimal toxicity. The other project is to optimize hair cell regeneration using human inner ear organoids, with the potential for new treatment for hearing loss.
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Additional Job Details (if applicable)
The research fellow will be responsible for performing modification of AAV and non-viral delivery vehicles (eg LNP), single cell RNAseq, bioinformatics analysis to identify candidates in hair cell regeneration and synapse formation. She will test the delivery vehicles for DNA, RNA and protein for inner ear cell types first in vitro followed by in vivo. She will conduct experiments to demonstrate the new delivery method together with new molecules identified will lead to functional restoration of hearing in mouse models of human genetic hearing loss. She will further conduct hair cell regeneration and synapse formation in human inner ear organoids with enhanced efficiency and optimize the drug-like cocktail for human application.
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