Site: The Brigham and Women's Hospital, Inc.

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

 

Job Summary

Principal investigators: Adel El Boueiz, MD, MMSc and Peter J. Castaldi, MD, MS
The Channing Division of Network Medicine at Brigham and Women's Hospital is looking for exceptional
Northeastern University trainees to join the Systems Genetics and Genomics group, advancing research on
chronic respiratory diseases, with a focus on identifying multi-omics biomarkers for chronic obstructive
pulmonary disease (COPD).
Brigham and Women’s Hospital, a major teaching hospital of Harvard Medical School, is an international leader
in healthcare, dedicated to improving global well-being through excellence in clinical care and groundbreaking
research. Serving patients from over 120 countries, the hospital has a legacy of innovation and impact.
This internship is within the Channing Division of Network Medicine, a research division in the Department of
Medicine at Brigham and Women’s Hospital and Harvard Medical School. We employ an integrated, networkbased, systems biology-driven approach to uncover the origins of complex diseases, with the goal of redefining
them by revealing their fundamental pathobiological mechanisms. This work aims to enable novel treatment and
preventive strategies grounded in revolutionary systems-driven disease classifications. The Division includes over
50 distinguished primary faculty members with expertise spanning epidemiology, statistics, bioinformatics,
genetics, epigenetics, transcriptomics, metabolomics, metagenomics, and network-based analyses of complex
human diseases.
The principal investigators’ research focuses on identifying novel COPD biomarkers, applying machine learning
to define its clinical and molecular basis, and developing clinical prediction tools using multi-omics data. COPD
affects up to 24 million individuals in the United States, contributing substantially to morbidity and mortality, yet
no disease-modifying therapies currently exist. Our group has led some of the largest genetic and multi-omics
studies in obstructive lung diseases, uncovering new molecular associations and pathways. The intern will work
with Dr. Castaldi and Dr. El Boueiz to identify novel multi-omics biomarkers and molecular subtypes of
emphysema using a systems biology approach. This project will leverage two large, well-phenotyped NIH-funded
studies (COPDGene and Lung Tissue Research Consortium (LTRC)) along with the team’s extensive expertise
in advanced imaging, multi-omics data analysis and machine learning.

 

Responsibilities: 
 Under the direction of the PIs and research staff, the applicant is expected to independently carry out daily 
research activities. 
 Work with our interdisciplinary team, consisting of epidemiologists, biostatisticians, computational 
biologists, translational scientists, and clinicians. 
 Review the literature and become familiar with the epidemiologic and multi-omics studies that are relevant 
to the research project. 
 Program and analyze data using R / Bioconductor and Linux. 
 Write abstracts, posters, and manuscripts. 
Qualifications: 
 Prior experience in programming languages and bioinformatics tools commonly used in computational 
biology. Most of our research projects use the R or Python. While some on the job learning is expected, 
interns who do not have some degree of exposure to programming will not be well-positioned for this 
position. 
 Excellent written and oral communication skills to convey research findings, collaborate with team 
members, and present at conferences. 
 Willingness and ability to adapt to new technologies, tools, and research directions as the field evolves. 
 Act with ethics and integrity, ensuring that all aspects of work meet or exceed professional standards. 
Build strong, positive working relationships with others (manager, peers, other coworkers) 
 Strong project management skills to plan, execute, and complete research projects on time with the ability 
to maintain a detailed and well-organized record of the research performed and the results obtained. 
 Demonstrate dependability (e.g., report consistently, and on time, for work, appointments, and meetings) 
 Ability to resolve technical problems and analytical skills if necessary 
 Accept feedback and use it to strengthen future performance 
Training goals: 
 Acquire advanced skills for analyzing complex biological data, including high-throughput data. 
 Develop advanced proficiency in programming and bioinformatics. 
 Develop strong critical thinking and problem-solving skills to address complex biological questions. 
 Publish research findings in reputable journals and present work at conferences. 
 Meet with the PIs at least twice weekly to discuss research findings, solicit feedback, evaluate progress, 
and provide appropriate support and mentoring. 
 Receive guidance on career planning and job search strategies.

 

Physical Requirements

Standing Frequently (34-66%)

Walking Frequently (34-66%)

Sitting Occasionally (3-33%)

Lifting Frequently (34-66%) 35lbs+ (w/assisted device)

Carrying Frequently (34-66%) 20lbs - 35lbs

Pushing Occasionally (3-33%)

Pulling Occasionally (3-33%)

Climbing Rarely (Less than 2%)

Balancing Frequently (34-66%)

Stooping Occasionally (3-33%)

Kneeling Occasionally (3-33%)

Crouching Occasionally (3-33%)

Crawling Rarely (Less than 2%)

Reaching Frequently (34-66%)

Gross Manipulation (Handling) Frequently (34-66%)

Fine Manipulation (Fingering) Frequently (34-66%)

Feeling Constantly (67-100%)

Foot Use Rarely (Less than 2%)

Vision - Far Constantly (67-100%)

Vision - Near Constantly (67-100%)

Talking Constantly (67-100%)

Hearing Constantly (67-100%)

 

Hybrid

 

181 Longwood Avenue

 

0

 

Per Diem

 

Day (United States of America)

 

Pay Range

$17.71 - $24.28/Hourly

 

Grade

2

 

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

 

2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

 

Mass General Brigham Competency Framework