Site: The McLean Hospital Corporation

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

 

Job Summary

Postdoctoral Fellow – T-Regulatory Cells and Cell Replacement Therapy
We are seeking a highly motivated Postdoctoral Fellow to join our research program focused on the role of regulatory T cells (Tregs) in improving outcomes in cell replacement therapy for neurodegenerative disease. The successful candidate will lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function.

The postdoctoral fellow will investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation. A major emphasis of the project will be to understand the mechanisms that influence Treg survival, persistence, and function post-transplantation. The fellow will also study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment.

In addition, the candidate will explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment. This work will integrate cellular immunology, transplantation biology, and neuroinflammation, with the goal of developing strategies that improve the safety and efficacy of regenerative therapies in the central nervous system.

The ideal candidate should have a strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field. Experience with T-cell biology, flow cytometry, in vitro immune assays, animal models, histology, and molecular or cellular techniques will be highly desirable. Candidates should be independent, scientifically rigorous, and enthusiastic about working in an interdisciplinary and translational research environment.

This position offers the opportunity to contribute to a growing area of investigation at the interface of immunology, neuroscience, and regenerative medicine, with strong potential for high-impact publications and translational relevance.

 

Position Summary

 

Default Add’l Job Description

 

Onsite

 

115 Mill Street

 

40

 

Regular

 

Day (United States of America)

 

1600 The McLean Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

 

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